The AJURI project aims to adapt decentralized antivenom therapy for Indigenous populations in the Brazilian Amazon, promoting safe, effective, and culturally appropriate treatment. The initiative evaluates the feasibility, clinical impact, and economic implications of this approach. The study will be conducted in Special Indigenous Health Districts (DSEIs) in the state of Amazonas, reaching around 250,000 people from approximately 100 ethnic groups.

The project is structured in three phases:

• Phases I and II: Translation, adaptation, and co-design of the intervention with the participation of Indigenous healers, community agents, healthcare professionals, and institutional leaders.

• Phase III: Quantitative assessment of the program’s feasibility, linguistic clarity, acceptability, and cultural appropriateness, involving 100 Indigenous participants, including health professionals and community members.

This initiative responds directly to the increasing demand for antivenom treatment in Indigenous communities across the region.