Naturalistic Developmental Behavioral lnterventions (NDBls), an evidence-based early autism spectrum disorder intervention approach, target key behaviors that help language development. While efforts to use NDBls are increasing worldwide, important gaps in our knowledge remain on whether the behaviors targeted by NDBls are cross-culturally valid. This study in South Africa, a multi-cultural setting, provides critical information on NDBl treatment targets and a novel digital outcome measure of treatment response.