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Research

Key One Health Themes

 

Epidemiological study of zoonotic pathogens: A key area of focus for the Duke One Health Network is zoonotic pathogens, which naturally transmit between animals and animals. We have a growing number of international collaborators conducting surveillance for zoonotic pathogens at the human-animal interface, including those associated with livestock farms, swine abattoirs and live bird markets. Example studies include a Study of Swine Workers and Their Pigs for Influenza Viruses and Porcine Rotaviruses for Evidence of Zoonoses in South Africa and Influenza Virus Surveillance in Vietnam. See more studies like these here.

Bioaerosol pathogen detection: Teams at Duke-NUS, Duke Kunshan University, and Duke University are all using cutting-edge 2-stage bioaerosol samplers developed by the National Institute for Occupational Safety and Health to conduct non-invasive surveillance for emerging respiratory viruses in poultry markets, swine farms, abattoirs, hospitals, clinics, and various other public spaces. Example studies include Using bio-aerosol sampling method to identify infectious airborne viruses in clinical settings and Refining Surveillance for Zoonotic Respiratory Viruses in Sarawak, Malaysia. See more studies like these here.

Field evaluation of pathogen diagnostics: Cases of tropical infectious diseases such as leptospirosis, melioidosis, malaria, dengue, chikungunya, and zika, may often be misidentified if diagnostic detection methods are not available or not specific. Accurate and quick diagnosis is critical to reduce such high mortality from such diseases. The Duke One Health team is currently conducting several diagnostic studies aimed at optimizing diagnostic tests for various human and animal pathogens. Example studies include Adapting a rapid lateral flow Burkholderia pseudomallei immunoassay in Sarawak, Malaysia: A Validation Study and Detection of Dengue, Chikungunya, and Zika Viruses by A New Multiplexing Platform Among Patients in Sarawak, Malaysia. See more studies like these here.

 Tropical infectious disease assessments: To better understand the epidemiology and prevalence of novel infectious disease pathogens, the Duke One Health team works with international partners to study patients with infectious diseases (often neglected tropical diseases). Our projects often help international partners adapt new diagnostic tools in their laboratories. Examples include Surveillance for Novel Respiratory Virus Infections among Patients Hospitalized with Pneumonia in Sarawak, Malaysia and Leptospirosis and Associated Acute Febrile Illness Surveillance in Sarawak, Malaysia. See more studies like these here.

Novel respiratory pathogen research and workshops: The Duke One Health Network conducts international workshops for detecting novel respiratory viruses emerging from the human-animal interface. The goal of these workshops is to increase epidemiological and laboratory capacity for public health professionals and veterinarians to conduct surveillance for novel respiratory viruses including coronaviruses, adenoviruses, influenza viruses and enteroviruses. Example workshops include Detecting Novel Respiratory Viruses that Emerge from the Human-Animal Interface – The Philippines and in Pakistan. See more studies like these here.

Workshops in conducting molecular surveillance for biological threats: The primary goal of these workshops is to increase laboratory capacity for detecting especially dangerous pathogens that may occur at the human and animal interface. This includes category A agents such as avian influenza viruses, coronaviruses, Bacillus anthracis (anthrax), Clostridium botulinum toxin (botulism), and Francisella tularensis (tularemia), that may play an important role in water and airborne zoonoses. Examples include Detecting and responding to the release of biological weapons SEGi University, Kuala Lumpur, Malaysia and Molecular Surveillance for Biothreat Agents. See more studies like these here.

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