The Exploring Cancer-Related Stigma in Sub-Saharan Africa (ECaSSA) study is a pilot research project aimed at understanding the social and cultural drivers of cancer stigma and its role in delaying care-seeking among cancer patients in Tanzania. Cancer stigma is a critical barrier to care, contributing to delayed presentation and poor outcomes, and its burden in Tanzania is rising, as cancer is now the third-leading cause of death in the country. The project adapted and culturally validated a cancer stigma scale to examine patient experiences of internalized, anticipated, and enacted stigma, as well as the association between stigma and timing of care-seeking. Preliminary findings have revealed significant patient concerns about disclosing their cancer status, as well as critical delays in treatment, with an average of six months from symptom onset to first seeking care, and a further five months on average to initiating cancer treatment. These findings are informing future interventions to reduce stigma and improve access to cancer care. Development and testing have taken place at the Cancer Care Centre at Kilimanjaro Christian Medical Centre (KCMC) in Moshi, Tanzania, in partnership with DGHI.