Projects

Current Support

(Gray) PI
06/17-08/17
Bass Connections and Duke Global Health Institute
A Pilot Study of Animal Workers and Their Environments for Novel Respiratory Viruses in Sarawak, Malaysia

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(Gray) PI
06/17-08/17
Duke Global Health Institute
Are Norovirus Infections Associated with Exposure to Animals in Sarawak, Malaysia?
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(Gray) PI
06/17-05/18
Vysnova and Duke Global Health Institute
Cross-sectional Surveillance for Novel Respiratory Virus Infections among Patients Hospitalized with Pneumonia in Sarawak, Malaysia

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(Gray) PI
Project title: Novel Respiratory Virus Surveillance and Identification Training Program,
Sarawak, Malaysia, United States/Singapore
: Our overall goal in this proposed research is to prevent and reduce the spread of emerging respiratory viruses by expanding surveillance in at-risk populations and optimizing methods of molecular detection of novel animal respiratory pathogens.

Sarawak Pic

Biosecurity Engagement Program (Gray) PI
09/01/2016-12/31/2017(year-to-year funding)
US State Department/ISN-CTR
United States Certificate in One Health Program: The primary purpose of this 9-credit-hour graduate program certificate is to support developing countries by providing their public health and veterinary health professionals with training in One Health-related disciplines (epidemiology, virology, environmental health, zoonotic diseases, food safety).

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(Gray) PI
05/01/2017-04/30/2018
Duke University, North Carolina Agromedicine Institute, and East Carolina University
Establishing Enviromental Bioaerosol Surveillance in North Carolina Swine Farms

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1R01AI108993-01A1 (Gray) PI
07/01/2014-06/30/2019
NIH/NIAID
Swine Influenza Virus Transmission in Confined Animal Feeding Operations, United States/China: In this controlled, 5-yr project, we will collaborate with leading Chinese infectious disease researchers and employ a One Health approach (human, animal, and environment) to study SIV transmission in Confined Animal Feeding Operations in Mainland China.

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1D43TW009373 (Gray) PI
09/01/2013-08/31/2018
NIH/Fogarty International Center
One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia
In this training program we address an immediate need in Mongolia for structured research training of young professionals to effectively control zoonotic infections and establish an US-Mongolia multidisciplinary partnership to address zoonotic disease burdens in Mongolia.

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NIH D43TW009373 (Gray) PI
2014 – 2016
Team 1, USA and Mongolia
Emerging Tick-Borne Pathogen threats in Mongolia: An investigation implementing a One Health framework.

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NIH D43TW009373 (Gray) PI
2015 – 2017
Team 2, USA and Mongolia
Detecting Influenza Virus in Rural Mongolia

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NIH D43TW009373 (Gray) PI
2016 – 2018
Team 3, USA and Mongolia
Emerging Zoonotic Enteric Parasite Disease Ecology and Epidemiology in Mongolia

Grant Pic (D43 team 3)

NIH D43TW009373 (Gray) PI
2017 – 2018
Team 4, USA and Mongolia
Identification and Surveillance of Mosquito-Borne Arboviruses in Mongolia among Vectors, Wildlife, Livestock and Humans

Grant Pic (D43 team 4)

06/2016 – 08/2016 (DGHI Master Student Thesis Funding)
USA and Mongolia
Determining the Prevalence of Tick Borne Pathogens in Small Mammal Reservoirs and Tick Species in Mongolia
Expanding on the Post Doc Team 1 project, This project aims to expand on the Duke Post Doc Team 1 project through investigation of tick borne pathogen prevalence in small mammal and tick species utilizing a One Health framework.

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(Gray) PI
Project Title: Comparison of three PRRSV assays in detecting viral RNA from swine serum in China, United States/China

In this study we will compare the performance of three PRRSV molecular assays against a collection of swine serum samples through collaboration between Life Technologies and 4 public health / veterinarian research laboratories in China.

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(Gray) PI
2015
Duke University, NC HHS, NC DoA
Evaluation of Occupational Exposure to Highly Pathogenic Avian Influenza (HPAI) H5N2 Virus in North Carolina
This study is a collaboration with the NC HHS and DoA to study individuals in North Carolina who have intense poultry exposure and search for evidence of infection of HPAI H2N2.

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(Gray) PI
2015
Duke University, NC HHS, NC DoA
An Epidemiological Study of Swine Workers and Their Family Members for Novel Zoonotic Respiratory Viruses and Antibiotic Resistant Enteric Bacteria
This study is a partnership between Duke One Health and Wake Forest University to study swine workers and their family members, searching for novel zoonotic respiratory viruses and for antibiotic resistant enteric bacteria.

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(Gray) PI
Detecting Emerging Respiratory Viruses in Mauritania at the Human Animal Interface
Our overall goal in this proposed research is to prevent and reduce the spread of emerging respiratory viruses by expanding surveillance in at-risk populations and optimizing methods of molecular detection of novel animal respiratory pathogens.

Grant pic Mauritania

Biosecurity Engagement Program (Gray) PI
2016 – 2017
US State Department/ISN-CTR
Remote Epidemiological One Health Training on Emerging Infectious Disease Threats for Scientists of Egypt, Iraq, Pakistan, and Philippines

Grant pic Egypt

(Gray) PI
Grant: SingHealth and Duke-NUS Research Collaborative Grant (2015 -2017)
Project title: Adenoviral respiratory infections in Singapore: identifying predictors for virulence, Singapore

This is a cross-sectional study to investigate epidemiological distributions of the clinical adenovirus types in Singapore and to identify risk factors for severe adenovirus disease

Grant Pic NUS (adeno)

(Gray) PI
Project title: Using bio-aerosol sampling method to identify infectious airborne viruses in clinical settings, Singapore

In this study we will perform non-invasive bio-aerosol sampling in a tertiary hospital’s patient areas during respiratory virus transmission seasons. The overall goal is to learn if bio-aerosol sampling in patient areas might substitute for direct patient sampling. If yes, it might be used as a noninvasive early warning system in respiratory virus transmission hot spots.

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(Gray) PI
Project title: Bioaerosol Sampling as an Early Warning System for Emerging Respiratory Threats, Singapore

Grant Pic NUS (bioaerosol)

(Gray) PI
Project title: Etiology of Acute Respiratory Infections in Vietnamese Military and Civilian Populations, Singapore

Grant Pic NUS (military)

(Gray) PI
Project title: Aerosol Detections and Characterizations of Novel Influenza Viruses (A,B,C,D), Corona-viruses, Adenoviruses, and Enteroviruses in Vietnam’s Swine Farms, Singapore

Grant Pic NUS (swinefarms)

(Gray) PI
Project Title:Education and Research Innovations in China (ERIC): Building Capacity Surveillance and Detection of Novel Respiratory Viruses at DKU, China

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(Gray) PI
Project Title: Detection of Molecular and Clinical Characteristics of HAdVs Infection among Elderly Pneumonia Patients, China

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Completed Research Support

R24TW009546-S1 (Gray) PI
09/22/2012-08/31/2015
NIH/Fogarty International Center, NIEHS, NIOSH
One Health Center for Environmental and Occupational Research Romania/United States (supplement): Capitalizing upon a previously existing network of research collaborations, in this pilot grant we are developing a One Health Center for Environmental and Occupational Research GEOHealth Hub at the Babeş-Bolyai University in Cluj-Napoca, Romania. The GEOHealth Hub will coordinate research and training collaborations in 11 additional academic centers located in Albania, Armenia, Georgia, Kazakhztan, and Moldova. The GEOHealth Hub will focus upon 3 research and training areas: 1) Aquatic Health, 2) Food Safety, and 3) Zoonotic Diseases.

(Gray) PI
Project title: To identify and characterize novel human & animal adenoviruses in water, Singapore

This collaboration with NUS environmental scientists sought to study water for adenoviruses, and then to identify the type of adenoviruses as emerging pathogen indicators and fecal source indicators.

P20ES022440-01 Gray (PI)
09/01/2012 – 09/30/2014
Fogarty International Center, NIEHS, NIOSH
One Health Center for Environmental and Occupational Research – United States: The GEOHealth Hub will coordinate research and training collaborations in 14 academic centers located in Albania, Armenia, Georgia, Romania, Kazakhztan, Moldova.  The GEOHealth Hub will focus upon 3 research and training areas: 1) Aquatic Health, 2) Food Safety, and 3) Zoonotic Diseases

HHSN266200700005C (Gray) PI
04/01/2007-03/31/2014
(year-to-year funding)
NIAID/Saint Jude Children’s Research Hospital
Fee Service Agreement with NIAID Center of Excellence:
The major goals of this project are to examine the characteristics of circulating avian (Romania) and equine (Mongolia) influenza viruses and to share same with other influenza investigators via St. Jude’s Children’s Research Hospital’s Center of Excellence for Influenza Research and Surveillance for further characterization.

W81XWJ-13-D-0023-01 (Gray) PI  
10/01/07-09/29/2014 (year-to-year funding)
Certificate in One Health Program: The primary purpose of this 9-credit-hour graduate program certificate is to support developing countries through providing their public health and veterinary health professionals with training in One Health-related disciplines (epidemiology, virology, environmental health, zoonotic diseases, food safety).

W81XWJ-13-D-0023-01 Gray (PI)
10/01/11-09/30/2014 (year-to-year funding)
US DoD /AFHSC/GEIS
Severe Acute Respiratory Infection (SARI) & Community Acquired Pneumonia (CAP) Surveillance Study in Republic of Georgia: The major goal of this project is to identify the main etiological agents causing SARI & CAP in outpatient and hospitalized patients in the Country of Georgia.

W81XWJ-13-D-0023-01 (Gray) PI
09/30/2013-09/29/2014 (year-to-year funding)
US DoD /AFHSC/GEIS
Surveillance for MERS-CoV and Other Viral Causes of CAP and SARI: Using previously developed algorithms and protocols, UF will aid international partners in adapting qPCR, or qRT-PCR techniques for the identification of respiratory viruses (MERS-CoV, other coronaviruses, enteroviruses, rhinoviruses, adenovirus, parainfluenza virus, influenza A & B viruses, respiratory syncytial virus, bocavirus, and human metapneumovirus) among patients diagnosed with CAP and SARI

W81XWJ-13-D-0023-01 (Gray) PI
09/30/2013-09/29/2014

US DoD /AFHSC/GEIS
One Health Training and Research Collaborations, China: This contract with support 3 Chinese graduate student and one Chinese junior faculty member in attending our Certificate in One Health training program. The funding will partially support professionals Mongolia, Nepal, Kyrgyzstan, Kazakstan, Macao, and the five autonomous regions of China (Xinjiang, Tibet, Ningxia, Inner Mongolia, and Guangxi) to attend a 2014 International Symposium on One Health Research.

NIAID Contract HHSN266200700005C Webby (PI)
4/1/2010-3/31/2014 

Surveillance for Avian Influenza in Romania and Equine Influenza in Mongolia: This subcontract involves searching for novel viruses in areas with historically frequent AIV & EIV incursions.

R01 AI068803 + ARRA Gray (PI)          
08/15/06 – 08/08/12
NIH/NIAID
Prospective Studies of Avian Influenza Transmission in Asia: This study seeks to identify risk factors for zoonotic influenza infection in H5N1 endemic areas in Cambodia and Thailand.  Analyses are ongoing but serological assays on the 1600 cohort members have document evidence of subclinical infections with highly pathogenic H5N1 avian influenza as well as with low-pathogens avian H9N2 viruses. This has resulted in 9 manuscripts.

I0179_10_UN Gray (PI)
10/01/07-09/30/2011 (year-to-year funding)
US DoD / GEIS
Identifying Risk Factors for Zoonotic Influenza Transmission to Man: This occupational study identifies risk factors for zoonotic influenza infection (Mongolia, Nigeria, Romania).  In Mongolia we are focusing upon occupational exposure to equine influenza, in Nigeria occupational exposure to avian influenza and in Romania we are focusing upon occupational exposure to swine influenza.